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This deficiency creates a cycle: low glutathione leads to more oxidative stress, which leads to more skin reactivity, which further depletes glutathione

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29,30 In 1985, oxidative stress was defined as a cellular imbalance between oxidants and reductants, leading to the differentiation of eustress and distress to describe oxidative stress states under physiological and pathological conditions, thereby advancing our understanding of oxidative stress in human diseases