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Cognitive or affective benefits are more evident in individuals with higher inflammatory or metabolic burden, whereas studies involving low-risk participants or short follow-up durations often report minimal effects (165, 208)

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B12 injections are intramuscular shots (meaning they go into the muscle), which are absorbed rapidly because of the great blood supply in the muscle

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Similarly, an animal model of diabetes-induced HF showed altered expression levels of copper transporter proteins and disturbed copper metabolism in rat cardiomyocytes (67)