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IGF-1 can also help decrease age-related muscle wasting (also called sarcopenia or muscle atrophy) by preserving lean muscle mass

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It is important to note that claims about increased energy expenditure in humans remain insufficiently evidenced at this stage, and the net glycaemic effects reflect observed trial outcomes rather than a straightforward mechanistic reduction in hepatic glucose output the concurrent glucagon receptor agonism may, in fact, influence hepatic glucose production in a complex and not fully characterised manner

But more common in middle-aged females

J Prev Med Public Health 45(6):353 Hosseinniaee S, Jafari M, Tavili A, Zare S, Cappai G (2023) Investigating metal pollution in the food chain surrounding a lead-zinc mine (Northwestern Iran)