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Despite recognising B12's importance on the central nervous system, research into its potential role in sleep disorders and its impact on subjective sleep quality has been sparse and often contradictory

These can contain synthesis byproducts, residual solvents, or even incorrectly sequenced peptides

Neurological manifestations are particularly concerning and may include peripheral neuropathy with paresthesias (tingling and numbness in hands and feet), ataxia, impaired proprioception and vibratory sense, cognitive impairment, memory loss, and in severe cases, subacute combined degeneration of the spinal cord

Zaman Javaheri, M.D

doi: 10.1016/j.aohep.2019.04.007 20