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10.1093/jn/125.7.1911 130 ManikandanR.BeulajaM.ArulvasuC.SellamuthuS.DineshD.PrabhuD.et al (2012)

p = 0.011

Regulatory Status AOD-9604 is not FDA-approved for any medical use and is listed by the FDA as a bulk drug substance that may present safety risks. Clinical development was halted after Phase IIb trials failed to meet efficacy endpoints. Summary AOD-9604 is a synthetic analog of the HGH 177191 fragment developed for fat-metabolism research

55 These potential therapeutics targeted towards rejuvenating, optimizing, and recruiting endogenous stem cells will likely increase the efficacy of cartilage tissue engineering techniques in the older patient population