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The timing of starting metformin may coincidentally overlap with the natural progression of these complications, leading patients to attribute vision changes to the medication rather than the disease process itself

ALS synthesis is strongly induced by growth hormone and suppressed by IL-1, thus potentially serving as a marker of growth hormone secretion and/or activity and of inflammation

[13] Their limitation for our question is generalizability: they describe severe, rare biology and cannot be extrapolated to common variants in healthy people

Pawlak, R., et al

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