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Similarly, glutathione peroxidase 4 (GPX4), an essential mitochondrial antioxidant enzyme protecting cells from lipid peroxidation and ferroptosis [126], and nuclear factor erythroid 2-related factor 2 (NFE2L2), which governs the oxidative stress response and mitochondrial homeostasis [127, 128], initially increase but then markedly decrease in later disease stages [115]

However, cold chain integrity during storage and transport is criticalespecially for liquid formulations

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Do not rub the point of insertion, as this can cause bruising