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The body relies on B12 to make red blood cells and keep the nervous system working, which is why some people need these injections more often

Ann Am Thorac Soc 19:20972100

Why success in pre-clinical studies for DPN primarily in rodents did not translate to human subjects has been a highly debated subject

Clinically relevant major bleeding was seen with 6.9% and 4.9% of patients who received lower- and higher-dose osocimab, respectively, and in 7.8% of patients who received a placebo

in contrast, claudin-2, a tight junction protein required for the formation of paracellular water channels that is highly expressed in leaky epithelial tissues, is upregulated in IBDs and promotes inflammation 27,46,47