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In a hippocampal neuronal culture model, Lions Mane extracts increased phosphorylation of CREB and promoted neurite outgrowth via ERK and cAMP pathways

This includes changes in functional activity in specific brain regions, such as reductions in the prefrontal cortex, caudate nucleus, and fronto-striatal regions when doing cognitive tasks (Sasikumar and Strafella, 2020)

K., Sharma A., Levering J., et al

Proc Natl Acad Sci USA (1996) 93:144927

Galy B, Ferring D, Benesova M, Benes V, Hentze MW (2004) Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo