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However, some individuals may struggle to absorb enough B12 through diet alone, making injections a reliable and effective solution

In conclusion, acromegaly patients have elevated serum IGF-1 levels because of the pathological hypersecretion of GH by the pituitary tumor

Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider

During the blinded data review an indication of period effect was noted and properly registered as follow up action according to the Statistical Analysis Plan of the trial protocol

Inflammation in UC is restricted to the superficial layers of the colon whereas, in CD, inflammation is transmural and can affect different regions of the GI tract including the upper part