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FGF21 also inhibits fibrogenesis in two mouse models of chemically-induced liver injury, dimethylnitrosamine- (217) or thioacetamide-induced fibrogenesis (220), by blocking TGF- expression and signaling, and NF-B activation

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However, when these oxidants accumulate within red cells, hemoglobin and other proteins are oxidized, leading to loss of function and RBC death

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