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Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages

Deacetylation Acetylation is a post-translational modification of chromatin components, particularly histones

Antonoff MB , Hess DJ, Saltzman RD, Acton RD

Favorable responses have also been seen in prostate, gastric, ovarian, and pancreatic cancers, showcasing its ability to target multiple pathways and overcome drug resistance