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This molecular crosstalk establishes a self-perpetuating cycle where adipose dysfunction progressively compromises peripheral tissue metabolic homeostasis

Proc Natl Acad Sci USA 107:2036420369 Liang C, Chen Q, Yi Q, Zhang M, Yan H, Zhang B, Zhou L, Zhang Z, Qi F, Ye S et al (2018) A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion

Large-scale targeted proteomics using internal standard triggered-parallel reaction monitoring (IS-PRM)

The procedure is practically painless and involves very little discomfort or recovery

The interaction involves 16 residues in the RBD and 20 residues in hACE2, which forms a network consisting of 14 hydrogen bonds and one salt bridge 19