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The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis

No approved therapeutic claims

The resultant carbonate derivatives create stable carbamate bonds with nucleophiles under mild, physiological conditions

Microglial surveillance and response mechanisms in the healthy and damaged brain In healthy brains, microglia continuously sense the alterations in CNS microenvironment by extending and retracting their processes

TXNTXNRD system TXN and TXNRD together constitute a vital antioxidant defense system, which is instrumental in averting the excessive buildup of ROS within the body [50]