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Readers should interpret findings as hypothesis-generating

Conversely, iron chelation strategies, using agents such as deferiprone, deferoxamine, and deferasirox, may be beneficial in early-stage or iron-addicted tumours by limiting proliferation and reducing oxidative damage to surrounding tissues (101104)

10.1016/j.fertnstert.2018.11.048 184 ShakibaeiM.Schulze-TanzilG.TakadaY.AggarwalB

Furthermore, downregulation of GPX4 via genetic deletion or chemical inhibition can lead to ferroptosis in T cells, while upregulation of GPX4 and genetic deletion of ACSL4 can suppress ferroptosis in CD8+ T cells (88, 89)

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