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You cannot overdose on B12 ( unlike many other vitamins and minerals ) This is a useful fact ( my doctor who refused me two-monthly injections said that an extra injection would be TOXIC

Confirmatory diagnostic studies should be performed prior to initiating therapy, if possible, and the patient should be followed with appropriate studies to demonstrate hematologic improvement (Hgb, hematocrit, RBC, reticulocyte count)

My internist, Sabena Toor, straddles that divide

This response to the intramuscular vitamin injection supports the notion that there is metabolic evidence of vitamin deficiency and it is common in the elderly, even in the presence of normal vitamin levels

Flier JS, Underhill LH, Le Roith D