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10thed.Brussels: Internation Diabetes Federation (2022)

This section covers what is known about safety along with theoretical concerns

The scaffold protein axin promotes signaling specificity within the Wnt pathway by suppressing competing kinase reactions

PDE5I tolerance is a common outcome of oral medication in ED patients and about 30% of ED patients have no obvious response to PDE5I treatment eventually (44)

Non-canonical pathway In contrast, the non-canonical NF-B pathway is activated by a narrower range of stimuli, including members of the TNF receptor superfamily such as lymphotoxin- receptor (LTR), B-cell activating factor (BAFF), and receptor activator of nuclear factor-kappa B ligand (RANKL) [44] (Fig