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The pain signal has been turned down, but the tissue has not knitted back together yet

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XO catalyzes the oxidation of hypoxanthine to xanthine and further the oxidation of xanthine to uric acid (Bortolotti et al

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One in vivo comparison of GHK versus GHK-Cu in rat experimental wounds found that GHK alone had no effect, and only the copper-bound GHK-Cu form produced a statistically significant increase in collagen accumulation evidence that the copper ion itself, not the peptide backbone alone, may be responsible for much of the collagen-stimulating activity