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Moreover, Ido1 is induced by the pro-inflammatory cytokine interferon gamma, whereas anti-inflammatory cytokines including IL-10 and transforming growth factor (TGF) inhibit Ido1, thus, activity of Ido1 in IECs reflects the balance between pro- and anti-inflammatory signals 171

In women with POCS, NAC at a dosage of 1200-1800 mg/day appears to be beneficial, while metformin treatment appears to be more successful [79]

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Considering the recent X-ray crystallography and cryo-EM data, which revealed that GSH and Glu could bind to different domains of GLR3.4 for ion channel activation 30 , it would be intriguing to investigate whether GSH binds to GLR3.3 and further determine the potential relationship between GSH and Glu in activating GLR3.3