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The formation of intra-neuronal inclusions called Lewy bodies (LB) is a pathologic hallmark of PD and often correlates with the degree of cognitive decline (Schneider et al., 2012)

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Possible molecular mechanisms involved in MTX-induced intestinal injury and mechanisms of actions of protective agents are graphically illustrated in Fig

A more extensive, longer-term study found that patients with mild cognitive impairment scored better on the Mini-Mental Status Exam and the Sleep Disorders Index when taking melatonin [106]