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By combining the pathological characteristics of RF (e.g., changes in ECM composition and receptor expression), we should utilize intelligent nano-systems, integrate microenvironment-responsive drug release and multi-target intervention, enhance carrier biocompatibility and targeting precision, avoid potential renal injury, and accelerate their clinical translation (Fig

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However, HRS reversal among transplant-free terlipressin patients with AH, regardless of baseline SCr, did predict 90-day survival (17/39, 43.6% vs 11/62, 17.7%, P =0.0047)

Recent studies have shown that anti-SARS-CoV-2 antibody levels decrease from 8 weeks after the onset of symptoms and that serum samples from 33% of SARS-CoV-2-infected patients display no neutralizing activity, even 39 days after symptom onset 10,14