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An enzyme activity inhibition results in liver steatosis development, which leads to activation of PPAR and is manifested in the presence of liver adenomas and carcinomas [201]

Similarly, a 6-fold reduction in bacterial burden was observed in the spleens of animals infected with the metZ compared to those of Rv-WT and complement strains at week 4 p.i

Machado Joseph disease severity is linked with gut microbiota alterations in transgenic mice

While PRT062607 is not selective for PINK1, it provides a scaffold for the development of more selective and potent inhibitors of PINK1 that could be used as chemical probes