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The excellent clinical manifestations of Tan IIA provide supportive evidence for targeting the GSH system in the treatment of heart diseases, which may be promising for transforming natural compounds from basic research to clinical applications

This non-invasive visualization technology not only validated tanshinone IIA's efficacy and mechanism but also established an effective imaging tool for detecting ferroptosis levels in CAD ( 4.2.3 Multimodal imaging for myocardial ischemia-reperfusion injury A 2024 study introduced a novel multimodal imaging platform for non-invasive in vivo identification of myocardial ischemia-reperfusion cardiac lesion markers

We will analyze thermodynamic stability and antioxidant activity using cell-free assays on recombinant protein

Moreover, the detachment of the DLG motif of Nrf2 from Keap1 prevents its ubiquitination and degradation, thus strengthening antioxidant defenses and inhibiting ferroptosis (68)

Building on the work of Dr