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Importantly, this form of plasticity can be initiated by any event that causes strong activation of a neuron, firing, and a rise of [Ca 2+ ] i to a sufficiently high level, meaning that it is capable of being engaged by almost any activity pattern that induced any of the diverse forms of homosynaptic plasticity discussed above

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This modulation appears selective, as AOD 9604 does not activate the growth hormone receptor or induce downstream IGF-1 signaling