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In contrast, topoisomerase I inhibitors (e.g., DXd, SN-38) have emerged as a highly successful class of DNA-damaging payloads, offering a favorable balance of high potency and manageable safety profiles, as evidenced by the success of ADCs like trastuzumab deruxtecan (T-DXd) [48]

In this sense, it is worthy of note that several BZ delivery platforms and formulations are been assayed in pre-clinical studies (Scalise et al., 2016

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