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Antigens activate the innate immune response through antigen-presenting cells and T cells, triggering an inflammatory cascade that also activates the adaptive immune system [44, 45]

Further evidence that Treg cells require ETC function comes from the observation that Treg cellspecific genetic loss of mitochondrial complex III function incurs fatal autoimmunity and increases antitumor immunity

With that being said, the support isnt overwhelming, and more research is needed to determine both efficacy and safety

Existing randomized window trials are small and focus on biomarker and microbiome modulation

The pathways of ROS production are diverse, involving numerous signaling cascades