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Increased heme oxygenase-1 (HO-1), a product of the Nrf2 target gene, inhibits adhesion molecules such as E-selectin and vascular cell adhesion molecule-1 (VCAM-1) expressed in endothelial cells via NF-B downregulation (139)

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Their cleavage is also of most importance to regulate secreted proteins such as thrombospondin, an extracellular glycocoprotein involved in cell-matrix adhesion