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Moreover, the specific peroxidation of PE phospholipids during ferroptosis may serve to counter the buffering effect of PE on membrane curvature, area per lipid and membrane thickness, initiating the ferroptosis process at the sites that would otherwise be maintaining membrane integrity

Curcumin protects neuronal cells against status-epilepticus-induced hippocampal damage through induction of autophagy and inhibition of necroptosis

T., Xun, P., Fly, A

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9 Toxicology and side effects Current evidence reveals an intrinsic paradox between therapeutic efficacy and safety profiles of bioactive compounds - no identified pharmacologically active agent completely avoids non-specific off-target effects on healthy tissues ( in vitro study demonstrated that shikonin has potent cytotoxicity against 15 types of cancer cells through mitochondrial dysfunction and can induce apoptosis