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doi:10.1002/iub.280 pmid:19937972 Bough KJ, Wetherington J, Hassel B, Pare JF, Gawryluk JW, Greene JG, Shaw R, Smith Y, Geiger JD, Dingledine RJ (2006) Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet

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To counter the enhanced efflux because of proteins like P-gp, overtly expressed in cancer cells, a higher dosage of the chemotherapeutic agent is considered, which would then directly lead to systemic toxicity

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