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Besides their direct antioxidant functions, flavonoids also act indirectly by inhibiting ROS-generating enzymes, such as mitochondrial succinoxidase, NADH oxidase, microsomal monooxygenase and others, as well as by upregulating and protecting antioxidant systems [238]

M.HofhuisA.van GrootheestG.VollaardA

Diets All mice were kept on normal chow diet until the start of the experiments

After treatment with HEM, HeA, HeC, and HeC, the cultures were incubated with MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) solution (5 mg/ml