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This randomized, placebo-controlled trial included 40 participants divided into two groups: a treatment group receiving 200 mg/day of oral EGCG alongside standard beta-blocker therapy, and a placebo group receiving only beta-blockers

Riboflavin supplementation resulted in clinical improvements in nine of ten patients treated [34,39-42,44,45]

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Author contributions Conceptualization, AM, HV, and LM

Specifically, the renoprotection effects of Tanshinone IIA and Ganoderic acid A were consistent with the previous works ( While the mechanism of UA reduction is linked to various factors, including the inhibition of XOD activity, anti-inflammatory and antioxidant effects, the interaction of transport regulation mechanisms holds a pivotal role ( In vitro experiments involving the heterologous expression of ABCG2 have confirmed that, in the presence of adenosine triphosphate (ATP), ABCG2 mediates urate transport ( 5 Conclusion This study demonstrated the therapeutic effect of Wuling capsule on HUA both in vivo and in vitro , primarily by protecting liver and kidney function, improving the regulation of cell apoptosis, and regulating UA-related transporters in the kidney to reduce serum UA levels