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To a stirred solution of methyl 3-(2-chlorophenyl)-1-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazole-6-carboxylate (467 mg, 1.21 mmol) in THF (2.6 mL) and MeOH (0.9 mL) was added a solution of NaOH (971 mg, 24.3 mmol) and water (2.6 mL)

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These results suggest that GSTM2 plays an important role in excess hepatic fat accumulation