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Neurologic symptoms as the only manifestation of B12 deficiency in a young patient with normal hematocrit, MCV, peripheral blood smear and homocysteine levels

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Since the 1990s, clinical research has been carried out by a study group on the Ministry of Health, Labour and Welfare, suggested that ultrahigh-dose mecobalamin, which is respectively 50 and 100 times the approved dosage of Methycobal, could have a clinical effect in ALS, and Eisai then conducted the Phase II/III clinical trial (Study 761) from 2006

These murine models were initially presented with corticosteroids, which reportedly contributed to severe muscular damage in these murine models

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