Specifically, knockout of acid ceramidase in podocytes ( Asah1 fl/fl /Podo Cre ) of healthy mice led to glomerular ceramide accumulation and a concomitant increase in albuminuria, podocyte foot process effacement, and glomerular permeability
Piacentini S, Polimanti R, Simonelli I, Donno S, Pasqualetti P, Manfellotto D, et al
Think of it as support from the inside that complements your existing routine rather than replacing topical care, professional facials, or any procedures you may choose to pursue separately
Technique Ultrasound-guided approach (preferred) Local Corticosteroid Injection at tendon sheath under Ultrasound guidance (see Shoulder Ultrasound) Approached in-plane to linear Ultrasound probe (probe short axis to anterior Shoulder - home position) Do not inject within tendon (and avoid circumflex artery within groove) Technique Landmark-based approach Images Landmarks Identify bicipital tendon in bicipital groove (proximal Humerus) Mark point of maximal tenderness over groove Injected with sterile technique (with Betadine preparation of skin) Direct needle parallel to bicipital groove (vertically oriented) Needle enters skin at 30 degrees oriented superiorly Do not inject bicipital tendon Infiltrate area around groove, but not into tendon Flow resisted when needle is inside tendon Withdraw needle slightly and retry Continue to withdraw until not in tendon Complications Bicipital tendon rupture Associated with intratendinous injection Do not inject bicipital tendon References
Why Rotation Matters (Lipohypertrophy and Beyond) The single most important habit in subcutaneous technique is site rotation deliberately moving the injection point each time so you never repeatedly hit the same tissue
