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doi: 10.1056/nejmoa1003466 24 BertrandAKostineMBarnetcheTTruchetetM-ESchaeverbekeT

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

Phase II clinical trials for inflammatory bowel disease reported no toxicity or adverse events in treated patients, though detailed safety data from these trials have not been published in peer-reviewed literature

for instance, lighter skin became apparent after administering high doses for treating other diseases

Supplementation appears to have no beneficial effect on performance in the absence of a nutritional deficit