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Furthermore, they observed a strong negative correlation between TRAP values and high plasma ascorbic acid levels in CF patients, suggesting that high concentrations of ascorbic acid might exert a pro-oxidant effect in the context of CF, thereby diminishing the overall extracellular antioxidant defense (Langley et al., 1993)

Moreover, MPH has been shown to promote ROS via RAC1and CAMK4 activation, although the evidence regarding whether MPH use indeed induces or reduces oxidative stress is not clear

[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Jong C.J., Sandal P., Schaffer S.W

Vitamin C synthesis, absorption, accumulation, and excretion follow a complex biochemical pathway converting glucose into glucuronic acid, a key metabolite for detoxification and metabolic regulation