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These results from both transcriptomic analysis and qRT-PCR indicated that the combination of (-)-Vestitol and Salviolone synergistically regulated the expression of the Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 genes within the Neuroactive ligand-receptor interaction and Calcium signaling pathway

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The approval was granted based on data from the Phase III NEURO-TTRansform study, where treatment with Wainua significantly reduced serum concentrations of the transthyretin (TTR) protein and significantly improved neuropathy impairment