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However, because of the episomal nature of the adenoviral and AAV vectors after cell entry, these viral vectors are most suited for therapeutic applications requiring only transient expression of the transgene (Russell, 2000, J

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It is also being investigated in combination with other investigational or approved compounds , such as semaglutide (a GLP-1 receptor agonist), under the name CagriSema

Conflict of interest TM was employed by the company Pieris Pharmaceuticals GmbH

doi: 10.1128/AAC.01885-12 123 CasulliJFifeMEHoustonSARossiSDowJWilliamsonEDet al