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2008;18(Suppl

J Am Chem Soc

The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

The liver stores significant amounts of B12, providing a reserve that can last several months to years, depending on the individual's metabolic needs and the severity of prior deficiency

Continuous long-term use is reserved for specific clinical situations under careful monitoring