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Leptin sensitivity plays a crucial role in energy status, thyroid hormone production, and reproductive status, and GLP1 receptors in the brain may have downstream effects on the leptin-melanocortin pathway 6m0s

Treatment with RG6179 was well tolerated, with no serious treatment-related adverse events, elevated IOP, or treatment-related new cataracts (Figure 6)

[5] The NH 2 -terminal extension decreases the folding rate of the precursor form of MBP relative to its mature form by at least 5 fold, but it has no effect on the unfolding rate