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This receptor activation triggers: Adenylyl cyclase stimulation leading to increased cyclic AMP production Activation of protein kinase A pathways within somatotroph cells Increased intracellular calcium mobilization necessary for hormone vesicle release Rapid growth hormone secretion from pre-formed intracellular storage pools Research demonstrates that sermorelin produces peak growth hormone elevations within 15-30 minutes of administration, with response magnitudes correlating with pituitary reserve capacity