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In recent years, the role of GPX3 in oxidative stress has been reported, for example: GPX3 can inhibit the expression of HIF1- by regulating ROS, thereby inhibiting the growth of melanoma cells (Yi et al., 2019)

479 Oxidative stress and ROS signaling associated with iron overload may mediate important factors in cardiac hypertrophy and heart failure

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A thermo-responsive alginate nanogel platform co-loaded with gold nanoparticles and cisplatin for combined cancer chemo-photothermal therapy

Our model also provides crucial insights for the design or optimization of artificial glutaredoxins, transition-state inhibitors and glutaredoxin-coupled redox sensors