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But Dan and I know underneath that there often lies a parasitic infection, a small intestinal bacterial overgrowth, a fungal overgrowth, or any number of things that are very treatable from a functional perspective

Interestingly, it has recently been suggested that Tfam heterozygous knockout mice, which undergo mild mtDNA depletion 49, also exhibit increased oxidative mtDNA damage susceptibility although the underlying mechanism is unclear 50