acetyl l carnitine and macular degeneration Antioxidants in Age-Related Degeneration: Lights Shadows Treatment and prevention of pathological

1 Introduction Vitamins of the B complex comprise a group of eight water-soluble vitamins that play a crucial role in maintaining optimal neurological function, such as energy production, DNA/RNA synthesis/repair, genomic and non-genomic methylation, and synthesis of neurochemicals ( Figures 1 , 2 ) ( Figure 1 Figure 2 Thiamine (B1) deficiency is often associated with beriberi, a syndrome mainly characterized by polyneuritis and/or cardiovascular symptoms (24)

Because SDH is the only enzyme that participates in both the TCA cycle and the ETC, we speculated that the ETC might be compromised in Gclc -deficient FoB, thus explaining the inhibition of SDH and the accumulation of succinate

Gomes M, Teixeira AL, Coelho A, et al

Jakaria, M., Belaidi, A

Sections were then rinsed in PBS, permeabilized, and blocked in a solution of PBS with 0.3% Triton X-100 containing 10% goat serum for at least 2 h at RT and then incubated with primary antibodies diluted in blocking serum O/N, at 4C