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Accordingly, PPARA and its target gene, CPT1A , were significantly downregulated in both primary hepatocytes (Extended Data Fig

Interestingly, transgenic animals with partial loss of imprinting of this locus show significant lethality in the third postnatal week, associated with developmental delay and failure to maintain UCP1 expression in BAT (141)

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Stability assay T m measurement of sp PlsY using its enzymatic activity To obtain T m using enzymatic assay, sp PlsY was purified as follows

Metabolic reprograming of microglia in the regulation of the innate inflammatory response