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Let's start with the most fundamental question

The system consists of a heterodimer composed of the light chain xCT (SLC7A11) and the heavy chain 4F2 (SLC3A2), which mediates a 1:1 exchange between intracellular glutamate and extracellular cystine

In seronegative Hashimotos, the person will still have the hypoechoic pattern on their thyroid gland that is seen with Hashimotos upon ultrasound examination

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