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And their N-lactoyl derivatives Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala, Ser-Leu-Ala-Lys-Gly-Asp-Glu-Glu, Ser-Leu-Ala-Asp-Glu-Lys-Gl, Lys-Gly-Ser-Leu-Ala, Asp-Glu-Glu, Lys-Gly-Asp-Glu-Glu, Glu-Glu-Asp-Gly-Lys or Asp-Glu-Glu (see Nakata et al, biosci

Epitalon also appears to modulate gene expression , particularly those related to oxidative stress response and inflammation both of which are critical components in the development of age-associated diseases

Cell Stem Cell 5 , 491503 (2009)

Dringen 2000)

[8] Patients with significant alcohol intake or thiamine deficiency also require precaution: chronic heavy alcohol use can deplete thiamine (vitamin B) and taking ALA in the setting of thiamine deficiency has been associated with serious health risks (including a condition resembling Wernickes encephalopathy)