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doi:10.1016/j.steroids.2014.06.012

The reported prevalence of use varies widely from 12 to 68% with families often not disclosing use of these medications or practices to their childs doctor (Bader and Adesman, Curr Opin Pediatr

Since the majority of substrates for NADase- CD38 are expected to be intracellular, the ecto-enzymatic activity of this enzyme represents an intriguing topological paradox (Figure 3b)

doi: 10.3389/fpls.2020.01182 84 PiacentiniD.RonzanM.FattoriniL.Della RovereF.MassimiL.AltamuraM.et al

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