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In the mentioned country, the cost of the burden of disease in 2013 was estimated to be over 20 billion dollars [1, 3]

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Association between MTHFR gene polymorphisms and the risk of autism spectrum disorders: a meta-analysis

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However, a 2003 systematic review highlighted differences in methodologies between early and later studies that make it difficult to compare results (104)

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The death receptor pathway directly activates caspase-8 by forming the Fas/tumor necrosis factor receptor 1 (TNFR1)-death inducing signaling complex, thereby activating caspase-3 or promotes apoptosis by amplifying the mitochondrial pathway (Li H

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