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Among these, the abnormal aggregation of -synuclein (-syn) to form Lewy bodies, mitochondrial dysfunction, oxidative stress, impaired protein homeostasis, and neuroinflammation (the activation of microglia and astrocytes leads to the release of various inflammatory factors, such as tumor necrosis factor- (TNF-) and interleukin-1 (IL-1), which exacerbate neuronal damage) constitute the key links in the pathophysiology of PD [6, 7]

doi: 10.1016/j.cell.2015.07.016 96 GuoWTanHYLiSWangNFengY

10.1155/2021/5565748 93 XiongB.FanM.WangZ.YangX.CaoS.ShenJ.et al (2024)

After each injection of nanobody or Fab, the chip was regenerated using 3 M GuHCl (IBA Lifesciences) before re-immobilization of fresh gB protein in the respective channels

( e ) Growth curves of CAR-T cells generated using primary human T cells from healthy donors showed that most CAR-T cells and EGFRt control T cells grew after a complete medium change to RPMI medium supplemented with dFBS, IL-2, and IL-15 on day 0